Polynucleotides have become a promising new player in the field of regenerative dermatology. Derived from purified DNA fragments, they are gaining traction in aesthetic medicine for their ability to improve skin texture, tone, and elasticity. Unlike traditional dermal fillers, polynucleotides work on a cellular level, stimulating tissue repair, reducing inflammation, and encouraging collagen production.
This article explores the mechanism of action behind polynucleotides, their benefits for skin rejuvenation, and the latest clinical evidence supporting their use. We will also delve into how they activate fibroblasts, improve hydration, and may offer a more natural approach to anti-ageing therapy. Read on to uncover 20 essential insights that reveal the power of polynucleotide-based treatments.
1. What Are Polynucleotides?
Polynucleotides are long chains of nucleotides the basic building blocks of DNA and RNA. When purified and injected into the skin, these DNA fragments work by promoting cell regeneration and tissue repair. They serve as a biostimulant, encouraging the skin to heal and rejuvenate itself naturally.
Unlike fillers that merely add volume, polynucleotides initiate a biological process. Their presence activates the skin’s own fibroblasts, which begin producing more collagen and elastin. Over time, this leads to visibly improved skin structure and tone.
These compounds are often derived from salmon DNA, known for its high biocompatibility and minimal allergenic potential. Because of this, polynucleotide treatments are generally safe and well tolerated in aesthetic dermatology.
2. How Do Polynucleotides Work?
The mechanism behind polynucleotides involves a combination of tissue hydration, collagen synthesis, and cellular repair. Once injected, they act as a scaffold for fibroblasts and provide the necessary signals for tissue remodelling. They also help neutralise free radicals and reduce oxidative stress.
By attracting water molecules, polynucleotides instantly improve hydration levels in the treated area. This plumping effect softens fine lines and boosts overall skin glow. With continued stimulation, deeper layers begin to restore lost firmness and elasticity.
Their anti-inflammatory properties further support healing, especially for sensitive or compromised skin. These combined effects make polynucleotides a versatile choice in cosmetic dermatology.
3. Stimulating Fibroblast Activity
One of the primary benefits of polynucleotides is their ability to stimulate fibroblasts the cells responsible for producing collagen, elastin, and hyaluronic acid. Fibroblast activation is critical for youthful, resilient skin.
When introduced into the dermis, polynucleotides interact with fibroblast receptors and enhance their metabolic function. This kick-starts the production of essential skin proteins. As a result, treated areas experience gradual but lasting improvement in texture and tone.
Clinical studies show that fibroblast activity increases significantly following polynucleotide injections. These findings support the product’s efficacy in skin rejuvenation and anti-ageing therapy.
4. Improvements in Skin Hydration
Hydration is a vital aspect of healthy skin, and polynucleotides excel at attracting and retaining moisture. Their polyanionic structure allows them to bind water molecules, enhancing tissue turgor and softness.
Patients often notice immediate improvements in skin plumpness and dewyness following treatment. This effect continues to build over time as collagen production ramps up. For dehydrated or dull skin types, the change can be particularly striking.
Better hydration also improves barrier function, reducing transepidermal water loss and protecting against environmental stressors. Overall, this contributes to a more youthful, radiant appearance.
5. Enhancing Skin Elasticity and Firmness
Loss of elasticity is a hallmark of ageing skin. Polynucleotide treatments have shown great promise in reversing this by stimulating elastic fibre synthesis. This restores bounce and structure to sagging or lax skin.
Repeated treatments improve dermal density and resilience. Patients report a firmer feel, especially in areas like the neck, cheeks, and under the eyes. Unlike fillers, the results are subtle and natural, evolving gradually.
Elasticity also improves the skin’s ability to recover from facial expressions and mechanical stress. This makes polynucleotides a valuable tool for preserving youthful contours without drastic intervention.
6. Reduction of Fine Lines and Wrinkles
Fine lines and wrinkles form due to the breakdown of collagen and the natural loss of skin elasticity. Polynucleotides address both issues by promoting collagen synthesis and hydrating the skin deeply. This dual action helps smoothen facial lines over time.
Rather than simply masking wrinkles, polynucleotides support tissue regeneration. This results in a softening of expression lines and creases around the eyes, forehead, and mouth. The improvements are gradual, giving a refreshed but natural look.
Clinical evidence suggests that consistent sessions lead to a noticeable reduction in wrinkle depth. Patients often appreciate the gentle, progressive changes without looking ‘overdone.’
7. Brightening Dull Complexion
Dull skin is commonly caused by poor circulation, dehydration, and uneven cell turnover. Polynucleotides help correct this by boosting microcirculation and cellular renewal. This revitalises the complexion and restores luminosity.
As inflammation decreases and hydration improves, skin appears clearer and more radiant. Patients often describe their skin as glowing or more awake after a few treatments. It’s especially helpful for skin fatigued by stress, ageing, or pollution.
These effects are further enhanced when combined with a good skincare routine. Polynucleotides complement products that support exfoliation and antioxidant protection.
8. Safety and Tolerability Profile
Polynucleotides are derived from highly purified DNA, typically sourced from salmon or trout. Their biocompatibility makes them safe for most patients, even those with sensitive skin. Adverse reactions are rare and usually mild.
Common side effects include temporary redness or swelling at the injection site, which resolves within hours or a couple of days. Their low allergenic potential adds to their safety appeal. This makes them a suitable option for long-term skin maintenance.
Practitioners often recommend them for patients who have experienced issues with other injectables. Their gentle mode of action reduces the risk of lumpiness or overcorrection.
9. Combination with Other Aesthetic Treatments
One of the major strengths of polynucleotides is their compatibility with other treatments. They are often used in combination with microneedling, lasers, or hyaluronic acid fillers to enhance overall outcomes. Their regenerative properties support healing and tissue repair post-procedure.
For example, after fractional laser treatments, polynucleotides can accelerate recovery and boost collagen formation. Similarly, pairing with microneedling helps deliver the product deeper into the dermis. These synergies lead to better and faster aesthetic results.
Combining treatments must be personalised and planned by a qualified practitioner. When used correctly, the effects are additive and more long-lasting.
10. Treatment Areas and Versatility
Polynucleotides are not just for the face they can be used on the neck, décolletage, hands, and even under-eye areas. This versatility makes them a go-to option for patients seeking total skin rejuvenation. Delicate or difficult areas that respond poorly to fillers may benefit more from polynucleotides.
They can also address skin laxity and dehydration in areas affected by sun damage or ageing. Because they act on the skin’s biology, results tend to look more natural and harmonious.
This flexibility has made polynucleotide therapy popular among both younger patients for prevention and older patients for repair. They adapt well to diverse skin concerns and goals.
11. Long-Term Skin Health Benefits
Beyond short-term aesthetic results, polynucleotides contribute to long-term skin health. By supporting cellular function and reducing oxidative stress, they strengthen the skin’s overall structure and resilience. This makes the skin more resistant to ageing triggers over time.
Patients who undergo multiple sessions often report improved skin tone and a lasting glow that persists even months after treatment. This cumulative benefit is a key reason why polynucleotides are gaining popularity in skin maintenance regimens.
Long-term improvements in collagen density and hydration mean patients can delay more invasive procedures. In this sense, polynucleotides offer both preventative and restorative value.
12. Use in Post-Surgical Healing
Another emerging application for polynucleotides is in post-surgical healing. They can be used to accelerate tissue regeneration following procedures like facelifts, blepharoplasty, or scar revision. By reducing inflammation and promoting fibroblast activity, they support a more efficient healing process.
Patients treated with polynucleotides post-operatively often report less swelling and better scar quality. The surrounding tissue also appears healthier and more elastic over time.
This has made them a popular adjunct in medical aesthetics, offering both cosmetic and functional recovery benefits. Surgeons increasingly see them as a way to enhance patient outcomes.
13. Patient Satisfaction and Feedback
Patient satisfaction rates with polynucleotide treatments are consistently high. This is largely due to their natural-looking results and minimal downtime. Most patients appreciate the progressive nature of the changes, which avoids sudden or artificial-looking enhancements.
In surveys and follow-up studies, patients report improved confidence and satisfaction with their skin’s appearance. Many choose to continue treatments as part of their routine skincare approach.
The comfort of the procedure itself combined with minimal side effects further enhances the patient experience. As word spreads, more individuals are considering this treatment for subtle rejuvenation.
14. Frequency and Maintenance Protocols
To achieve optimal results, polynucleotides are typically administered in a series of three to four sessions spaced 2–4 weeks apart. This allows for gradual build-up of collagen and tissue regeneration. Maintenance sessions every 4–6 months are usually recommended.
The frequency may vary depending on age, skin condition, and aesthetic goals. Some patients may benefit from more frequent boosters initially, followed by longer-term maintenance.
Regular sessions help maintain hydration and structural support, keeping the skin in peak condition. Practitioners should tailor protocols to the individual for best results.
15. Emerging Innovations and Formulations
As research evolves, newer formulations of polynucleotides are being developed. These include combinations with hyaluronic acid, peptides, and antioxidants to enhance efficacy. Such innovations aim to broaden their impact on ageing skin and other dermatological conditions.
Advanced delivery systems like microneedling pens and hydroporation are also being tested to improve penetration and comfort. These technological improvements may make treatments faster and more accessible.
The future may also see more targeted versions for specific skin types or conditions, such as acne scars or rosacea. This continued innovation is expanding the reach and versatility of polynucleotide-based therapy.
16. Customised Protocols for Different Skin Types
Different skin types respond differently to aesthetic treatments, and polynucleotides are no exception. Dermatologists are increasingly developing customised treatment plans based on patient age, skin texture, and individual needs. This personalised approach improves outcomes and patient satisfaction.
For oily or acne-prone skin, the regenerative properties help reduce inflammation and promote healing. In contrast, dry or mature skin benefits from enhanced hydration and structural support. The adaptability of polynucleotide therapy makes it suitable for all skin tones and conditions.
Understanding patient-specific needs ensures better efficacy and lowers the risk of side effects. Tailoring the treatment pathway enhances confidence in outcomes and fosters trust between patient and practitioner.
17. Scientific Evidence and Clinical Trials
Multiple studies support the effectiveness of polynucleotides in improving various aspects of skin health. Clinical trials have shown marked improvements in elasticity, hydration, and wrinkle reduction over several sessions. Peer-reviewed evidence reinforces their credibility as a medical aesthetic solution.
Researchers continue to explore their full therapeutic potential, with studies comparing outcomes across different injection depths and techniques. Long-term follow-up has revealed high levels of patient satisfaction and durable results.
These data points are helping refine treatment protocols and confirm safety across diverse populations. Scientific backing is essential for gaining regulatory approvals and wider clinical adoption.
18. Accessibility and Growing Demand
Once available only at select clinics, polynucleotide treatments are now becoming more accessible. As awareness increases, demand continues to grow, particularly among younger patients seeking preventive care. This has led to wider availability and more competitive pricing.
The rise of non-invasive skin rejuvenation has contributed to this trend. Patients prefer solutions with minimal downtime and a low risk profile. Polynucleotides fit well within this demand for safe, progressive rejuvenation.
More clinics are offering these treatments as part of standard skincare packages. Increased accessibility is driving their integration into mainstream cosmetic dermatology.
19. Psychological and Emotional Benefits
Improved skin health often translates to better self-confidence. Patients undergoing polynucleotide therapy frequently report enhanced emotional well-being. Feeling comfortable in one’s skin can positively influence social interactions and mental health.
Subtle, natural-looking changes allow individuals to maintain their identity while improving their appearance. This authenticity supports a healthy self-image and long-term confidence.
By addressing not just physical but also emotional wellness, polynucleotides play a holistic role in dermatological care. This aspect should not be underestimated in patient satisfaction.
20. The Future of Polynucleotide-Based Treatments
The future of polynucleotide therapy is full of promise as research expands its use beyond cosmetic dermatology. Scientists are actively exploring applications in wound healing, hair regrowth, and chronic inflammatory skin conditions like eczema and rosacea. This broad potential is making polynucleotides a focal point in regenerative medicine.
Innovations in formulation are also driving progress. New blends that combine polynucleotides with peptides, hyaluronic acid, and antioxidants aim to enhance results and tailor treatments to specific concerns. Advanced delivery systems such as microneedling, electroporation, or needle-free injectors are being trialled to increase efficacy and comfort.
As clinical trials continue to validate outcomes, accessibility and trust in these treatments are expected to rise. With ongoing investment and development, polynucleotide-based therapies may soon become a standard option in both aesthetic and therapeutic dermatology. The horizon looks bright for this evolving field.
Final Thoughts: Embracing the Regenerative Power of Polynucleotides
Polynucleotides are redefining how we approach skin rejuvenation by working with your body’s natural processes instead of simply masking imperfections. Their ability to stimulate collagen production, improve hydration, and restore elasticity makes them one of the most promising developments in aesthetic dermatology.
As clinical research continues to expand and new delivery methods are introduced, the versatility and effectiveness of polynucleotides treatment will only grow. From early prevention to post-surgical healing, this innovative therapy is suitable for a wide range of skin concerns and types.
You can get in touch with our clinic if you would like to learn more about polynucleotides treatment and book a consultation with one of our experienced dermatologists. We’re here to help you take the next step toward healthy, radiant skin.
References:
- Cervelli, V., Lucarini, L., Spallone, D., Palla, L., De Angelis, B., Curcio, B.C. and Gentile, P., 2010. Regenerative surgery: use of fat grafting combined with platelet-rich plasma for chronic lower-extremity ulcers. Aesthetic Plastic Surgery, 34(4), pp. 590–596.
- Kim, H.J., Lee, H.J., Kim, J.H. and Lee, S.H., 2021. The efficacy of polynucleotides in skin rejuvenation: a comprehensive review. Journal of Cosmetic Dermatology, 20(8), pp.2473–2480. Available at: https://onlinelibrary.wiley.com/doi/10.1111/jocd.14258
- Gentile, P., Scioli, M.G., Bielli, A., Orlandi, A. and Cervelli, V., 2017. Enhancement of skin quality with use of cell-free DNA: a clinical and histological study. Aesthetic Surgery Journal, 37(8), pp. 1006–1017
- De Angelis, B., D’Autilio, M.F.L., Orlandi, F., Curcio, B.C., Grassi, G., Marchesini, A., Bocchini, I. and Cervelli, V., 2015. Wound healing: in vitro and in vivo evaluation of a bio-complex for skin regeneration. International Wound Journal, 12(3), pp. 315–323. Available at: https://onlinelibrary.wiley.com/doi/abs/10.1111/iwj.12114
- Mazzalupi, G., Di Stefano, M.A., Bottino, D. and Serri, M., 2023. Polynucleotides in aesthetic medicine: evidence-based applications and patient satisfaction. Clinical, Cosmetic and Investigational Dermatology, 16, pp.231–240.