<linearGradient id="sl-pl-bubble-svg-grad01" linear-gradient(90deg, #ff8c59, #ffb37f 24%, #a3bf5f 49%, #7ca63a 75%, #527f32)
0%
Loading ...

Why Do Some Skin Conditions Keep Coming Back Even After Treatment?

Aug 7, 2025

It’s a frustrating experience shared by many: you finally get some relief from a persistent skin condition whether it’s acne, eczema, rashes, fungal infections, or something else only to find that the problem reappears a few weeks or months later. You may have followed your dermatologist’s advice to the letter, applied the prescribed creams or taken the medication exactly as directed, and still, the condition comes back.

This kind of recurring issue can leave you feeling disheartened, confused, and even helpless. It’s not uncommon to wonder whether the treatment was effective at all, or if something deeper is causing the issue.

The truth is, there are several reasons why certain skin problems tend to return after treatment. Sometimes the root cause hasn’t been fully addressed. Other times, environmental triggers or lifestyle factors continue to aggravate your skin. And in many cases, people stop treatment too early or don’t follow a long-term plan to manage flare-ups.

In this article, I’ll break down some of the most common reasons why skin conditions can keep coming back even when you’ve already sought medical help. We’ll look at what causes relapses, the role of incomplete treatment, and how triggers like stress, diet, and weather can play a part. I’ll also explain how dermatologists approach chronic or recurring skin conditions, including strategies for long-term care and prevention to help you get more consistent, lasting results.

Why Do Skin Conditions Keep Coming Back?

If you’ve ever felt like your skin was finally improving only to watch your condition flare up again soon after you’re not alone. Chronic or recurring skin problems are more common than you might think. Conditions like acne, eczema, psoriasis, and fungal infections often follow a cycle of improvement followed by relapse, leaving patients feeling frustrated and unsure about what went wrong.

Let’s explore the most common factors behind recurring skin issues:

1. Incomplete Treatment

One of the most frequent causes of recurring skin conditions is stopping treatment too early. It’s tempting to pause medication once the visible symptoms start to fade, but this can backfire. In many cases, the underlying inflammation, infection, or imbalance may still be active beneath the surface even if your skin looks better.

Acne Treatment

Take acne, for example. Many people stop applying topical retinoids, benzoyl peroxide, or using oral medications as soon as their breakouts subside. However, acne is a long-term condition linked to oil production, bacteria (like Cutibacterium acnes), and clogged pores. Discontinuing treatment too soon allows these factors to re-accumulate, leading to a new wave of breakouts.

Fungal Infections

Fungal infections, such as ringworm or athlete’s foot, often appear to clear within a few days of applying antifungal creams. But the visible improvement doesn’t mean the fungus is fully eradicated. If the medication is stopped too early, the infection can quickly resurface sometimes more stubborn than before.

Eczema and Topical Steroids

Similarly, people with eczema often reduce or stop using topical corticosteroids as soon as redness and itching decrease. However, the inflammation may not be fully under control, leading to another flare-up within days or weeks.

Why It Matters:
Dermatologists strongly recommend completing the full course of treatment, even when symptoms seem to improve. This ensures that the root cause of the condition is fully addressed and significantly lowers the risk of recurrence. It also helps prevent the development of resistance in cases where antibiotics or antifungals are used.

2. Underlying Triggers and Environmental Factors

Even with consistent treatment, many skin conditions tend to reappear when triggered by specific internal or external factors. Often, these triggers aren’t addressed in the initial treatment plan especially if the focus was only on symptom relief rather than prevention. Identifying and managing these ongoing influences is crucial to keeping your skin healthy over time.

Internal Triggers

These are factors within the body that can influence your skin’s behaviour and immune response, often contributing to recurring symptoms.

Hormonal Imbalances
Hormones play a powerful role in skin health. For instance, fluctuations in oestrogen, progesterone, and androgens can stimulate oil production in the skin, contributing to acne flare-ups. That’s why many people experience breakouts around menstruation, during pregnancy, or in the perimenopausal or menopausal years. Similarly, hormonal shifts can aggravate conditions like melasma or seborrhoeic dermatitis.

Diet and Gut Health
While the link between food and skin isn’t always straightforward, certain dietary habits have been associated with flare-ups in common skin conditions. High-glycaemic foods, processed sugar, dairy, and alcohol may trigger acne, eczema, or rosacea in some individuals. Additionally, poor gut health or food sensitivities may contribute to inflammation, which can manifest as skin irritation or redness. Everyone’s skin reacts differently, so keeping a food and symptom diary can help identify personal triggers.

Stress
Stress is a well-known aggravator of chronic skin issues. When you’re stressed, your body releases cortisol and other stress hormones that can suppress immune function, increase oil production, and heighten inflammation. As a result, conditions like psoriasis, hives, acne, and eczema often flare during stressful periods. Even if you’re following treatment protocols, unmanaged stress can override their benefits.

External Triggers

These are environmental or lifestyle-related elements that come into contact with the skin and may worsen or reignite existing conditions.

Weather Changes
The climate has a direct effect on the skin’s barrier and hydration levels. In hot, humid weather, sweat and moisture buildup can create an ideal environment for fungal infections, especially in skin folds. Conditions like eczema or heat rashes may also worsen due to increased perspiration and friction. Conversely, cold, dry air during winter months strips moisture from the skin, aggravating dryness, flaking, and conditions like rosacea or atopic dermatitis.

Allergens and Irritants
Contact with allergens or harsh chemicals can easily lead to a resurgence of symptoms, especially in people with sensitive or allergy-prone skin. Common culprits include:

  • Dust mites, mould spores, or pet dander in the home
  • Pollen during seasonal changes
  • Fragranced lotions, soaps, or laundry detergents
  • Harsh exfoliants, alcohol-based toners, or acidic skincare products

Even certain fabrics like wool or synthetic blends can irritate the skin and trigger a reaction. If exposure to these elements continues without modification, the skin condition may persist or return, despite treatment.

3. Incorrect Diagnosis

Sometimes, what appears to be a recurring skin condition isn’t actually a relapse it’s a misdiagnosis. When the initial condition is not correctly identified, the treatment plan may target the wrong issue altogether. As a result, the skin either doesn’t respond or appears to improve temporarily, only to flare up again when the underlying problem remains unresolved.

This is more common than many people realise. Several skin conditions can look quite similar on the surface, especially in their early stages or when symptoms are mild. Without expert evaluation, it’s easy to mistake one condition for another, leading to ineffective or even counterproductive treatment.

Common Examples of Misdiagnosis:

Fungal Acne vs. Traditional Acne
One of the most common diagnostic errors is confusing fungal acne (technically known as Malassezia folliculitis) with bacterial or hormonal acne. While both present as small, uniform bumps often on the forehead, back, or chest fungal acne is caused by yeast overgrowth rather than clogged pores or bacteria. Standard acne treatments like benzoyl peroxide or antibiotics may actually make fungal acne worse, allowing it to persist or spread.

Seborrhoeic Dermatitis vs. Eczema or Psoriasis
Seborrhoeic dermatitis can mimic both eczema and psoriasis, especially when it appears on the scalp, face, or ears. It typically causes red, flaky patches that can resemble other inflammatory skin conditions. If misdiagnosed as eczema and treated solely with moisturisers or steroid creams, the condition may not improve or may return quickly once treatment is stopped.

Rosacea vs. Acne
Rosacea is another condition that can be mistaken for acne, especially when pustules are present. However, the underlying cause is very different. Treating rosacea with traditional acne medications may offer limited relief or trigger further irritation, making the skin worse over time.

Contact Dermatitis vs. Fungal Infection
An allergic or irritant reaction such as contact dermatitis can sometimes mimic a fungal infection with symptoms like redness, scaling, and itching. If a steroid cream is prescribed incorrectly, it may suppress symptoms short term but also weaken the skin barrier, allowing any existing fungal infection to thrive and re-emerge later.

4. Medication Resistance or Tolerance

Another reason why skin conditions may come back or stop responding to treatment altogether is due to the development of resistance or tolerance to certain medications. This can happen when a treatment is used too frequently, for too long, or without appropriate breaks, leading the skin (or the pathogens involved) to adapt and render the medication less effective over time.

This is particularly common in the treatment of long-term or recurring conditions like acne, eczema, psoriasis, and fungal infections, where medications are often used repeatedly.

Antibiotic Resistance

In acne treatment, both oral and topical antibiotics are commonly prescribed to reduce inflammation and bacterial overgrowth. However, extended or improper use of these antibiotics can lead to antibiotic resistance where the Cutibacterium acnes bacteria (formerly Propionibacterium acnes) become less responsive to the medication. When this happens, breakouts may return or worsen, even though the same treatment initially worked well.

To prevent resistance, dermatologists often limit the duration of antibiotic use and pair it with other treatments like benzoyl peroxide or retinoids to enhance efficacy and reduce reliance on a single therapy.

Steroid Tolerance and Tachyphylaxis

Topical corticosteroids are widely used to treat inflammatory skin conditions like eczema, psoriasis, and contact dermatitis. While they can be highly effective in the short term, prolonged use especially of mid- to high-potency steroids can lead to tachyphylaxis. This refers to a gradual reduction in responsiveness, where the same steroid no longer produces the desired anti-inflammatory effect.

In some cases, patients also experience withdrawal symptoms after stopping steroids, including redness, burning, or rebound flares, further complicating long-term management.

Antifungal Resistance

Although less common, resistance to antifungal medications can occur as well, particularly in individuals who use over-the-counter creams inconsistently or stop treatment too soon. In such cases, the fungus may survive and become more resilient, making subsequent infections harder to treat.

How Dermatologists Create Long-Term Management Plans

While short-term treatments may provide temporary relief, the key to lasting skin health lies in developing a thoughtful and consistent long-term management plan. Dermatologists understand that many skin conditions are chronic or cyclical, and as such, they require more than just symptom control they require ongoing care tailored to each patient’s unique skin type, triggers, and lifestyle.

1. Identifying and Addressing Triggers

A major part of successful skin management is uncovering the hidden causes behind recurring symptoms. Dermatologists take a comprehensive look at your medical history, skincare routine, daily habits, and environmental exposures to identify potential triggers that may be contributing to the problem.

Once these triggers are identified, they’ll offer practical, personalised advice to help you minimise or eliminate them from your routine. Some common strategies include:

  • Switching to hypoallergenic products: If you have sensitive or allergy-prone skin, dermatologists may recommend fragrance-free or non-comedogenic products to avoid irritation. Ingredients like alcohol, artificial fragrance, or certain preservatives can be especially problematic for conditions like eczema or contact dermatitis.
  • Adjusting your diet: If food sensitivity is suspected such as dairy, sugar, spicy foods, or processed snacks dermatologists might suggest an elimination approach to see if symptoms improve. For example, cutting down on dairy has been helpful for some acne sufferers, while people with rosacea might benefit from avoiding alcohol and spicy meals.
  • Stress management: Since stress is a known flare-up trigger for conditions like psoriasis, eczema, and acne, dermatologists may recommend stress-reduction strategies such as yoga, deep breathing exercises, cognitive behavioural therapy (CBT), or simply getting more quality sleep.
  • Making clothing or lifestyle adjustments: In cases where skin irritation is due to physical factors like friction, sweat, or fabric texture, simple changes such as wearing breathable cotton clothing, avoiding tight-fitting garments, or switching laundry detergents can help prevent flare-ups especially in fungal infections or heat-induced rashes.

2. Prescription of Maintenance Treatments

Even after your skin has improved, dermatologists often recommend continuing with a lower-intensity or preventive treatment plan. The goal is not just to treat flare-ups when they occur, but to reduce the chances of them happening in the first place.

Maintenance treatments vary depending on the condition, but they may include:

  • Topical retinoids: These vitamin A derivatives are often prescribed in lower strengths as part of long-term acne, pigmentation, or anti-ageing regimens. They help keep pores clear, reduce inflammation, and support cell turnover, even after breakouts have subsided.
  • Barrier-repair moisturisers: For conditions like eczema, daily use of moisturisers containing ceramides, urea, or hyaluronic acid can help strengthen the skin barrier and prevent dryness or itching from returning. Dermatologists often tailor these recommendations based on your skin’s hydration needs.
  • Antifungal or antibacterial creams: For patients prone to recurrent infections, dermatologists might suggest applying preventive creams in susceptible areas (e.g., underarms, groin, feet) on a scheduled basis to keep microbial overgrowth in check.
  • Low-dose oral medication: In some cases such as with hormonal acne or autoimmune-related skin conditions long-term oral medications like hormonal regulators, immunosuppressants, or biologics may be part of the ongoing care plan.

3. Regular Follow-Ups

Skin conditions often change over time due to shifts in lifestyle, hormonal balance, or environmental exposure. That’s why regular follow-up appointments are so important.

Dermatologists typically schedule check-ins at set intervals every few months or even annually, depending on the severity and stability of the condition. During these appointments, they’ll assess how well your skin is responding, adjust dosages, switch medications if necessary, and address any new concerns that may have arisen.

They may also perform in-clinic procedures such as:

  • Chemical peels for acne or hyperpigmentation
  • Cryotherapy for warts or growths
  • Phototherapy for psoriasis or vitiligo
  • Skin swabs or biopsies if something unusual develops

4. Patient Education

Perhaps one of the most important components of long-term skin health is empowering patients with knowledge. Dermatologists spend time educating their patients not just about their diagnosis, but also about how to properly care for their skin at home between visits.

This includes:

  • Understanding your skin type and condition: Knowing whether your skin is oily, dry, sensitive, or combination helps you choose the right products and avoid common mistakes like over-cleansing or using incompatible ingredients.
  • Recognising early warning signs: If you can spot the initial signs of a flare-up such as itching, redness, or bumps you can act quickly to prevent it from escalating. Dermatologists often provide action plans for what to do when symptoms return.
  • Proper use of products: Many patients misuse their prescriptions without realising it applying too much, too little, or mixing incompatible products. Your dermatologist will walk you through how and when to apply each product for maximum benefit.
  • Long-term skincare planning: Dermatologists help you build a realistic routine that supports your skin goals, whether it’s reducing fine lines, preventing breakouts, or managing chronic inflammation.

Final Thought: Take Control of Recurring Skin Problems

Skin conditions can be persistent and frustrating, but with the right treatment plan, their recurrence can be significantly reduced. By completing treatment courses, identifying and managing triggers, and working closely with a dermatologist in London, you can keep your skin healthy and under control.

If you’re struggling with recurring skin issues, you can get in touch with our dermatologist in London to book a consultation and develop a personalised long-term treatment plan.

References:

  1. Nemeth, V., Syed, H.A. & Evans, J., 2024. Eczema. StatPearls [online]. Treasure Island (FL): StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK538209
  2. Zaenglein, A.L., Pathy, A.L., Schlosser, B.J., Alikhan, A., Baldwin, H.E., Berson, D.S., Bowe, W.P., Graber, E.M., Harper, J.C., Kang, S. and Keri, J.E., 2023. Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 88(3), pp.657–674. Available at: https://www.jaad.org/article/S0190-9622(23)03389-3/fulltext
  3. Eichenfield, L.F., Tom, W.L., Berger, T.G., Krol, A., Paller, A.S., Schwarzenberger, K. and Simpson, E.L., 2023. Guidelines of care for the management of atopic dermatitis in adults. Journal of the American Academy of Dermatology, 88(4), pp.847–872. Available at: https://www.jaad.org/article/S0190-9622(23)00004-X/fulltext
  4. Liu, H., Yang, X., Chen, T., Wang, L., and Zhang, Y., 2024. Acne treatment: research progress and new perspectives. Frontiers in Medicine, Available at: https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1425675/full
  5. Tang, A., Sharma, A., Draelos, Z. and Lee, C.H., 2025. Artificial intelligence-enabled precision medicine for inflammatory skin diseases. arXiv preprint, [online] Available at: https://arxiv.org/abs/2505.09527